Is the combination of Covishield, Covaxin safe? The study revealed


A hospital in Hyderabad has conducted a pilot study to determine the safety profile of a mixture of two COVID-19 vaccines, Covishield and Covaxin.


The study, conducted by AIG Hospitals along with researchers from the Asian Healthcare Foundation, showed that the combination of Covishield and Covaxin is 'absolutely safe and has no adverse effects on any of the participants'.

A total of 330 healthy volunteers, who were not vaccinated and had no history of COVID-19 infection, were selected and screened for SARS-CoV-2 antibodies for the study. Of these, 44 (13%) participants were found to be seronegative, i.e., they did not have antibodies related to COVID.

Dr. D Nageswara Reddy, President, AIG Hospital said “One of the emergent findings of the study is seropositivity among our population. 87% of the participants who did not vaccinate and never tested positive for COVID-19, They had antibodies related to COVID. This means our population has developed significant antibodies against COVID-19 because of the huge delta wave we endured."

India, like many other countries, is currently witnessing a third-wave trend driven by the Omicron version. Although early data indicates that the wave will be mild compared to Delta with fewer hospitalizations, a larger portion of the population may be affected, according to the researchers.


As the central government approves "preventable" vaccine doses for healthcare workers, the elderly, and vulnerable populations, it is important to detect cross-immunity resulting from a mix of available vaccines. It is also important that the safety profiles are well established before various vaccines are administered as prevention or booster doses, the researchers said.