New Delhi: Founder have recognized an RNA molecule that helps cancer cells in rising opportunistically, contribution scientists a fresh target for drug growth. The research showed that NEAT1, a non-coding RNA, plays a significant role in the survival of extremely dividing cells and in exacting of cancer cells. This conclusion can help develop fresh drugs that target NEAT1, in order to kill cancer cells more effectively. As a non-coding RNA, NEAT1 is not translated into a protein. It does, however, contribute to the configuration of so-called ‘paraspeckles’, subnuclear particles that can be found in the cell nuclei of cancer cells. The function of these particles has remained obscure. Though extremely conserved through evolution, NEAT1 appears to be not necessary for usual embryonic development and adult life as mice lacking the non-coding RNA are viable and healthy. Research concluded that the appearance of NEAT1 in the cell nucleus is keeping pace by p53.
This protein plays a significant role in defensive people next to cancer and is known as ‘the guardian of the genome, Carmen Adriaens, PhD student at Flanders Institute for Biotechnology (VIB), KU Leuven, Leuven, Belgium. The founder also establish that NEAT1/paraspeckles are necessary for the survival of extremely dividing cancer initiating cells and that pests lacking NEAT1 are secluded from developing skin cancer. This way that cancer cells can ‘hijack’ the survival code of NEAT1 for their own good. Professor Jean-Christophe Marine from VIB-KU Leuven conveyed that,’ We expected NEAT1 to be a tumor suppressor, since it is regulated by p53. Instead, it turned out that NEAT1 helps cancer cells in growing opportunistically.