Washington: scientist discovered a new anti-inflammatory drug that can stall the damaging effects of alcohol on the fetal brain.
Ibuprofen reduced neuroinflammation and behavioral signs of alcohol exposure in a rat model of fetal alcohol spectrum disorders (FASD).
Derick Lindquist from The Ohio State University said that the study was the first to directly link alcohol-induced inflammation in the hippocampus to cognitive impairment later in the life. The findings could have eventual implications reaching beyond fetal alcohol spectrum disorders, because neuroinflammation is a hallmark of many neurological diseases he added.
After birth some of the animals were exposed to alcohol for four to nine days. Alcohol-exposed rats given ibuprofen had lower levels of inflammation in the brain than those given saline solution. Twenty-five days later they also exhibited enhanced long-term memory.
While it’s too soon to speculate on implications in humans, it could pave the way for future research into potential treatments for fetal alcohol spectrum disorders and other neurological problems, said lead author Molly Goodfellow.