New Delhi: Mounting effectual genetic strategies to manage mosquitoes, scientists have isolated a gene that determines maleness in the class of mosquito that is accountable for transmitting malaria. The study establishes that this gene, named Yob, could be deadly for the female inhabitants of the mosquito species which is initially responsible for malaria broadcast. Lead founder Jaroslaw Krzywinski, Head of the Vector Molecular Biology group at The Pirbright Institute in Britain conveyed that, their research may have far-reaching implications for the control of malaria. The study, available in the journal Science, describes classification and characterisation of Yob which determines the male sex in the malaria mosquito Anopheles gambiae. To recognize Yob, the founders used high-throughput sequencing to sample all transcripts (genetic messages) shaped in the Anopheles gambiae male and female embryos.
Subsequent to contrast of the sequencing data, they found, wholly in males, remains of transcripts corresponding to Yob. Supplementary study showed that Yob is prearranged on the Y chromosome, and that action of Yob was partial to males. Unexpectedly, Yob transcripts are highly harmful to females. When injected into mixed-sex early embryos of Anopheles gambiae, Yob kills females previous to they hatch from eggs, but leaves male growth unaffected. Equally, silencing normal embryonic Yob activity is lethal to males. These results indicate that, apart from determining maleness, Yob is pivotal for the control of an additional fundamental developmental procedure, called dosage return, which balances levels of transcripts from genes situated on the single X chromosome in males and on two X chromosomes in females. Krzywinski conveyed that, the female-killing property of Yob gives us an priceless tool for the engineering of male-only Anopheles strains suitable for malaria control in the future.